Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?

Abstract The pathophysiology of COVID comprises an exaggerated pro-inflammatory response. Hypothalamic-pituitary-adrenal (HPA) axis has a crucial role in various inflammatory conditions and modulated immunological Limited evidence is available regarding the incidence effect HPA dysfunction COVID-19. Although cortisol levels have only been estimated few studies, dehydroepiandrosterone sulfate (DHEAS) release from adrenal gland not explored yet. In this mini review, authors discuss (DHEA) DHEAS acute stress response modulation. Various effects demonstrated different diseases. specific inhibitory DHEA on interleukin 6 (IL-6) could be paramount importance Further, supplementation already proposed conditions, like rheumatoid arthritis. COVID-19 may help to understand as well possibility repurposing drug for mitigating